Pimavanserin could be useful for treating psychosis in Parkinson disease
نویسندگان
چکیده
منابع مشابه
Pimavanserin for psychosis in patients with Parkinson’s disease
Pimavanserin is a potent 5-HT2A inverse agonist and 5-HT2C inverse agonist, with 5-fold greater affinity for the 5-HT2A receptor.1 Although antagonists block agonist actions at the receptor site, inverse agonists reduce the level of baseline constitutive activity seen in many G protein-coupled receptors. This medication is FDA approved for treating hallucinations and delusions associated with P...
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Psychotic symptoms are common in drug treated patients with Parkinson's disease (PD). Visual hallucinations occur in about 30% and delusions, typically paranoid in nature, occur in about 5%. These problems, particularly the delusions, cause great distress for patient and caregivers, and are among the most important precipitants for nursing home placement. Psychotic symptoms carry a poor prognos...
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متن کاملPimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial.
BACKGROUND Parkinson's disease psychosis, which includes hallucinations and delusions, is frequent and debilitating in people with Parkinson's disease. We aimed to assess safety and efficacy of pimavanserin, a selective serotonin 5-HT2A inverse agonist, in this population. METHODS In our 6 week, randomised, double-blind, placebo-controlled study, we enrolled adults (aged ≥40 years) with Parki...
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ژورنال
عنوان ژورنال: Nature Reviews Neurology
سال: 2013
ISSN: 1759-4758,1759-4766
DOI: 10.1038/nrneurol.2013.233